Griseofulvin
An antifungal medication taken orally to treat fungal infections of the skin, hair, and nails, working by interfering with fungal cell division and disrupting the microtubule structure that fungi need to reproduce. Treatment typically requires several weeks to months depending on the site of infection. It has also been investigated for potential anticancer properties in cell growth studies.
Peso Molecular
352,8000 g/mol
LogP
2,20
TPSA
71,10 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
COC1=CC(=O)C[C@@H](C)[C@]12Oc1c(Cl)c(OC)cc(OC)c1C2=O
InChI
InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
Molecular Formula
C17H17ClO6
HBD / HBA
- / 6
Ligações Rotacionáveis
3
Átomos Pesados
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
An antifungal medication taken orally to treat fungal infections of the skin, hair, and nails, working by interfering with fungal cell division and disrupting the microtubule structure that fungi need to reproduce. Treatment typically requires several weeks to months depending on the site of infection. It has also been investigated for potential anticancer properties in cell growth studies.
Disrupts microtubule dynamics by binding to tubulin, preventing the formation of the mitotic spindle and arresting cell division at metaphase. This induces apoptosis in rapidly dividing cells.
Yes, Griseofulvin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL562. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 441140. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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