Meprednisone
This synthetic corticosteroid is used to reduce inflammation and suppress the immune system in a variety of conditions including allergies, asthma, and autoimmune diseases. Like other corticosteroids, it works by mimicking the effects of cortisol, the body's natural stress hormone.
Peso Molecular
372,5000 g/mol
LogP
1,90
TPSA
91,70 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI
InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1
Molecular Formula
C22H28O5
HBD / HBA
2 / 5
Ligações Rotacionáveis
2
Átomos Pesados
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
This synthetic corticosteroid is used to reduce inflammation and suppress the immune system in a variety of conditions including allergies, asthma, and autoimmune diseases. Like other corticosteroids, it works by mimicking the effects of cortisol, the body's natural stress hormone.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Meprednisone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201148. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284587. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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