Methyclothiazide
A thiazide diuretic used to treat high blood pressure and fluid retention (edema) caused by heart failure, kidney disease, or liver disease. It works by increasing urine output to reduce fluid and lower blood pressure.
Peso Molecular
360,2000 g/mol
LogP
1,40
TPSA
126,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O
InChI
InChI=1S/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16)
Molecular Formula
C9H11Cl2N3O4S2
HBD / HBA
2 / 7
Ligações Rotacionáveis
2
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A thiazide diuretic used to treat high blood pressure and fluid retention (edema) caused by heart failure, kidney disease, or liver disease. It works by increasing urine output to reduce fluid and lower blood pressure.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Methyclothiazide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1577. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4121. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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