Nefazodone

CHEMBL623 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

470.0 g/mol

LogP

4.3

Phase

4

This antidepressant is used to treat major depression by affecting the balance of serotonin and norepinephrine in the brain. Due to rare but serious liver toxicity risks, its use has declined significantly and requires careful medical monitoring.

Peso Molecular

470,0000 g/mol

LogP

4,30

TPSA

51,60 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Generalized Anxiety Disorder Major Depressive Disorder

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1

InChI

InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3

Molecular Formula

C25H32ClN5O2

HBD / HBA

- / 5

Ligações Rotacionáveis

10

Átomos Pesados

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

This antidepressant is used to treat major depression by affecting the balance of serotonin and norepinephrine in the brain. Due to rare but serious liver toxicity risks, its use has declined significantly and requires careful medical monitoring.

Yes, Nefazodone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL623. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4449. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

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Nefazodone no PillFYI

Estrutura

Dados Rápidos

Fórmula: C25H32ClN5O2

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.