Olmutinib

CHEMBL3786343 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

486.6 g/mol

LogP

4.7

Phase

4

A third-generation EGFR inhibitor that targets the T790M resistance mutation in non-small cell lung cancer, developed to treat patients who have progressed on earlier EGFR inhibitors. It selectively blocks mutant EGFR signaling while sparing the normal form of the receptor.

Peso Molecular

486,6000 g/mol

LogP

4,70

TPSA

111,00 Å²

Regra dos 5 de Lipinski

Aprovado

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1

InChI

InChI=1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

Molecular Formula

C26H26N6O2S

HBD / HBA

2 / 8

Ligações Rotacionáveis

7

Átomos Pesados

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

A third-generation EGFR inhibitor that targets the T790M resistance mutation in non-small cell lung cancer, developed to treat patients who have progressed on earlier EGFR inhibitors. It selectively blocks mutant EGFR signaling while sparing the normal form of the receptor.

Yes, Olmutinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3786343. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 54758501. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estrutura

Dados Rápidos

Fórmula: C26H26N6O2S

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.