Pergolide
A dopamine receptor agonist used to treat Parkinson's disease and restless leg syndrome by stimulating dopamine receptors in the brain to compensate for the loss of dopamine-producing neurons. It was withdrawn in many countries after being linked to heart valve damage (fibrotic valvulopathy).
Peso Molecular
314,5000 g/mol
LogP
4,20
TPSA
44,30 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCCN1C[C@H](CSC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
InChI
InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
Molecular Formula
C19H26N2S
HBD / HBA
1 / 2
Ligações Rotacionáveis
4
Átomos Pesados
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A dopamine receptor agonist used to treat Parkinson's disease and restless leg syndrome by stimulating dopamine receptors in the brain to compensate for the loss of dopamine-producing neurons. It was withdrawn in many countries after being linked to heart valve damage (fibrotic valvulopathy).
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Pergolide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL531. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 47811. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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