Pyrithione Zinc
Pyrithione zinc is a coordination complex of zinc and pyrithione with broad-spectrum antifungal and antibacterial activity that acts by disrupting membrane proton gradients and inhibiting key metabolic enzymes in Malassezia and other microorganisms. It is widely used in over-the-counter shampoos for dandruff and seborrheic dermatitis treatment, and in topical preparations for various dermatological conditions.
Peso Molecular
317,7000 g/mol
TPSA
52,90 Ų
Mecanismo de Ação
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
[O-][n+]1ccccc1[S-].[O-][n+]1ccccc1[S-].[Zn+2]
InChI
InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
Molecular Formula
C10H8N2O2S2Zn
HBD / HBA
- / 4
Ligações Rotacionáveis
2
Átomos Pesados
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Pyrithione zinc is a coordination complex of zinc and pyrithione with broad-spectrum antifungal and antibacterial activity that acts by disrupting membrane proton gradients and inhibiting key metabolic enzymes in Malassezia and other microorganisms. It is widely used in over-the-counter shampoos for dandruff and seborrheic dermatitis treatment, and in topical preparations for various dermatological conditions.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Pyrithione Zinc is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200471. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 26041. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="pyrithione-zinc"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/pyrithione-zinc/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/pyrithione-zinc/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/pyrithione-zinc/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="pyrithione-zinc"></drugfyi-drug>