Rilpivirine
A non-nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy for HIV-1 infection in treatment-naive patients with low viral loads. It is taken once daily and is available in combination pills that simplify HIV treatment regimens.
Peso Molecular
366,4000 g/mol
LogP
4,50
TPSA
97,40 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
Cc1cc(/C=C/C#N)cc(C)c1Nc1ccnc(Nc2ccc(C#N)cc2)n1
InChI
InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
Molecular Formula
C22H18N6
HBD / HBA
2 / 6
Ligações Rotacionáveis
5
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A non-nucleoside reverse transcriptase inhibitor used as part of combination antiretroviral therapy for HIV-1 infection in treatment-naive patients with low viral loads. It is taken once daily and is available in combination pills that simplify HIV treatment regimens.
Inhibits viral reverse transcriptase, blocking the conversion of viral RNA to DNA and preventing viral replication in infected host cells.
Yes, Rilpivirine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL175691. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6451164. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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