Ritlecitinib
Ritlecitinib is an irreversible covalent inhibitor of JAK3 and the TEC family of kinases (including ITK, RLK, BTK, BMX, and TXK) that blocks signaling from multiple pro-inflammatory cytokines through the JAK3/STAT pathway and T-cell receptor signaling through the TEC kinase pathway. It is approved for the treatment of alopecia areata in adults and adolescents, and is under investigation in other immune-mediated inflammatory conditions.
Peso Molecular
285,3400 g/mol
LogP
2,10
TPSA
73,90 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Irreversibly inhibits Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway that drives the survival and proliferation of malignant B cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Irreversibly inhibits Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway that drives the survival and proliferation of malignant B cells.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C
InChI
InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
Molecular Formula
C15H19N5O
HBD / HBA
2 / 4
Ligações Rotacionáveis
3
Átomos Pesados
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Ritlecitinib is an irreversible covalent inhibitor of JAK3 and the TEC family of kinases (including ITK, RLK, BTK, BMX, and TXK) that blocks signaling from multiple pro-inflammatory cytokines through the JAK3/STAT pathway and T-cell receptor signaling through the TEC kinase pathway. It is approved for the treatment of alopecia areata in adults and adolescents, and is under investigation in other immune-mediated inflammatory conditions.
Irreversibly inhibits Bruton's tyrosine kinase (BTK), a key enzyme in the B-cell receptor signaling pathway that drives the survival and proliferation of malignant B cells.
Yes, Ritlecitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4085457. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 118115473. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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