Sincalide
Sincalide is a synthetic C-terminal octapeptide fragment of cholecystokinin (CCK) used diagnostically to stimulate gallbladder contraction for cholescintigraphy and to assess pancreatic exocrine function. By binding to CCK receptors in the gallbladder smooth muscle and pancreatic acinar cells, it mimics endogenous CCK-induced contraction and enzyme secretion. It enables dynamic assessment of gallbladder ejection fraction and pancreatic secretory capacity in nuclear medicine and GI function tests.
Peso Molecular
1143,3000 g/mol
LogP
-2,60
TPSA
486,00 Ų
Regra dos 5 de Lipinski
Reprovado
Mecanismo de Ação
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
InChI
InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
Molecular Formula
C49H62N10O16S3
HBD / HBA
13 / 19
Ligações Rotacionáveis
33
Átomos Pesados
78
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Sincalide is a synthetic C-terminal octapeptide fragment of cholecystokinin (CCK) used diagnostically to stimulate gallbladder contraction for cholescintigraphy and to assess pancreatic exocrine function. By binding to CCK receptors in the gallbladder smooth muscle and pancreatic acinar cells, it mimics endogenous CCK-induced contraction and enzyme secretion. It enables dynamic assessment of gallbladder ejection fraction and pancreatic secretory capacity in nuclear medicine and GI function tests.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Sincalide is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1121. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9833444. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="sincalide"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/sincalide/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/sincalide/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/sincalide/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="sincalide"></drugfyi-drug>