Sulfamethizole

CHEMBL1191 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

270.3 g/mol

LogP

0.5

Phase

4

Sulfamethizole is a short-acting sulfonamide antibiotic with high urinary concentrations used specifically for the treatment of uncomplicated urinary tract infections caused by susceptible gram-positive and gram-negative bacteria. Its rapid renal excretion achieves high antibacterial concentrations in urine, making it particularly suited for lower urinary tract infections. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase to block folate synthesis.

Peso Molecular

270,3000 g/mol

LogP

0,50

TPSA

135,00 Å²

Regra dos 5 de Lipinski

Aprovado

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

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SMILES

Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1

InChI

InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)

Molecular Formula

C9H10N4O2S2

HBD / HBA

2 / 7

Ligações Rotacionáveis

3

Átomos Pesados

17

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Sulfamethizole is a short-acting sulfonamide antibiotic with high urinary concentrations used specifically for the treatment of uncomplicated urinary tract infections caused by susceptible gram-positive and gram-negative bacteria. Its rapid renal excretion achieves high antibacterial concentrations in urine, making it particularly suited for lower urinary tract infections. Like all sulfonamides, it inhibits bacterial dihydropteroate synthase to block folate synthesis.

Yes, Sulfamethizole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1191. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5328. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Estrutura

Dados Rápidos

Fórmula: C9H10N4O2S2

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.