Sulfapyridine
Sulfapyridine is a sulfonamide antibacterial used as an active metabolite of sulfasalazine and independently for the treatment of dermatitis herpetiformis and linear IgA bullous dermatosis, where it suppresses neutrophil-mediated cutaneous inflammation. Sulfasalazine is cleaved in the colon by bacteria to release mesalazine (anti-inflammatory) and sulfapyridine, the carrier that ensures colonic delivery. In dermatitis herpetiformis, its anti-inflammatory mechanism likely involves suppression of neutrophil chemotaxis and oxidative burst.
Peso Molecular
249,2900 g/mol
LogP
0,00
TPSA
93,50 Ų
Regra dos 5 de Lipinski
Aprovado
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1
InChI
InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
Molecular Formula
C11H11N3O2S
HBD / HBA
2 / 5
Ligações Rotacionáveis
3
Átomos Pesados
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Sulfapyridine is a sulfonamide antibacterial used as an active metabolite of sulfasalazine and independently for the treatment of dermatitis herpetiformis and linear IgA bullous dermatosis, where it suppresses neutrophil-mediated cutaneous inflammation. Sulfasalazine is cleaved in the colon by bacteria to release mesalazine (anti-inflammatory) and sulfapyridine, the carrier that ensures colonic delivery. In dermatitis herpetiformis, its anti-inflammatory mechanism likely involves suppression of neutrophil chemotaxis and oxidative burst.
Yes, Sulfapyridine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL700. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5336. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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