Taurolidine
Taurolidine is a synthetic derivative of the amino acid taurine with broad-spectrum antimicrobial and antineoplastic properties, acting by releasing formaldehyde-like reactive intermediates that disrupt microbial cell walls and induce tumor cell apoptosis. It has been used as a catheter lock solution to prevent catheter-related bloodstream infections and is investigational for various cancers including ovarian cancer. Its dual antimicrobial and antitumor activity makes it a unique agent in oncology.
Peso Molecular
284,4000 g/mol
LogP
-1,70
TPSA
116,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1
InChI
InChI=1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
Molecular Formula
C7H16N4O4S2
HBD / HBA
2 / 8
Ligações Rotacionáveis
2
Átomos Pesados
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Taurolidine is a synthetic derivative of the amino acid taurine with broad-spectrum antimicrobial and antineoplastic properties, acting by releasing formaldehyde-like reactive intermediates that disrupt microbial cell walls and induce tumor cell apoptosis. It has been used as a catheter lock solution to prevent catheter-related bloodstream infections and is investigational for various cancers including ovarian cancer. Its dual antimicrobial and antitumor activity makes it a unique agent in oncology.
Yes, Taurolidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105420. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 29566. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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