Ticarcillin
Ticarcillin is an extended-spectrum carboxypenicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and leading to cell lysis. It is particularly active against Pseudomonas aeruginosa and is used in combination with clavulanate (Timentin) for serious gram-negative and mixed infections including nosocomial pneumonia, urinary tract infections, and intra-abdominal infections. Its anti-pseudomonal activity addressed a major gap in penicillin coverage.
Peso Molecular
384,4000 g/mol
LogP
0,80
TPSA
178,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C(=O)O)c3ccsc3)C(=O)N2[C@H]1C(=O)O
InChI
InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1
Molecular Formula
C15H16N2O6S2
HBD / HBA
3 / 8
Ligações Rotacionáveis
5
Átomos Pesados
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Ticarcillin is an extended-spectrum carboxypenicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and leading to cell lysis. It is particularly active against Pseudomonas aeruginosa and is used in combination with clavulanate (Timentin) for serious gram-negative and mixed infections including nosocomial pneumonia, urinary tract infections, and intra-abdominal infections. Its anti-pseudomonal activity addressed a major gap in penicillin coverage.
Yes, Ticarcillin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1449. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 36921. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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