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Tizanidine

CHEMBL1079 Phase 4 Aprovado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
253.7 g/mol
LogP
1.1
Phase
4

This muscle relaxant is used to manage muscle spasticity — the tightening or stiffening of muscles — caused by conditions such as multiple sclerosis or spinal cord injury. It works by blocking nerve signals in the brain and spinal cord that trigger muscle contractions. It can cause significant drowsiness and a drop in blood pressure, especially when first starting treatment.

Peso Molecular

253,7100 g/mol

LogP

1,10

TPSA

90,40 Ų

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Pain Management Rheumatoid Arthritis Migraine Insomnia Melanoma Multiple Sclerosis Stroke Gout Chronic Pain

Mecanismo de Ação

Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.

Estrutura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Clc1ccc2nsnc2c1NC1=NCCN1

                

                

                
                

                    
InChI

                    
InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H8ClN5S

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Ligações Rotacionáveis

                        
2

                    

                    
                    
                    

                        
Átomos Pesados

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Perguntas frequentes

                

                    
                    

                        
                        

                            
This muscle relaxant is used to manage muscle spasticity — the tightening or stiffening of muscles — caused by conditions such as multiple sclerosis or spinal cord injury. It works by blocking nerve signals in the brain and spinal cord that trigger muscle contractions. It can cause significant drowsiness and a drop in blood pressure, especially when first starting treatment.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tizanidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1079.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5487.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Aviso Médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.