Tofogliflozin
Tofogliflozin is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor that blocks glucose reabsorption in the proximal renal tubule, promoting urinary glucose excretion (glucosuria) and lowering blood glucose in an insulin-independent manner. It is approved in Japan for type 2 diabetes and is under investigation for non-alcoholic fatty liver disease due to its effects on hepatic steatosis through caloric loss and indirect metabolic improvements. Its selectivity for SGLT2 over SGLT1 reduces the risk of GI adverse effects from intestinal glucose malabsorption.
Peso Molecular
386,4000 g/mol
LogP
1,50
TPSA
99,40 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CCc1ccc(Cc2ccc3c(c2)[C@]2(OC3)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1.O
InChI
InChI=1S/C22H26O6.H2O/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22;/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3;1H2/t18-,19-,20+,21-,22+;/m1./s1
Molecular Formula
C22H26O6
HBD / HBA
4 / 6
Ligações Rotacionáveis
4
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Tofogliflozin is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor that blocks glucose reabsorption in the proximal renal tubule, promoting urinary glucose excretion (glucosuria) and lowering blood glucose in an insulin-independent manner. It is approved in Japan for type 2 diabetes and is under investigation for non-alcoholic fatty liver disease due to its effects on hepatic steatosis through caloric loss and indirect metabolic improvements. Its selectivity for SGLT2 over SGLT1 reduces the risk of GI adverse effects from intestinal glucose …
Yes, Tofogliflozin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105711. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 46908929. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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