Triclosan
Triclosan is a chlorinated aromatic compound with broad-spectrum antimicrobial activity that inhibits bacterial enoyl-acyl carrier protein reductase (ENR, FabI), a key enzyme in bacterial fatty acid synthesis required for cell membrane integrity and growth. It is widely used in consumer products (toothpastes, surgical scrubs, antimicrobial soaps) and has been investigated for treatment of infectious diseases and potential antiproliferative effects in cancer cell lines. Regulatory restrictions have been placed on triclosan in rinse-off consumer products due to concerns about endocrine disruption, antimicrobial resistance selection, and lack of proven clinical benefit.
Peso Molecular
289,5000 g/mol
LogP
5,00
TPSA
29,50 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
InChI
InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
Molecular Formula
C12H7Cl3O2
HBD / HBA
1 / 2
Ligações Rotacionáveis
2
Átomos Pesados
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Triclosan is a chlorinated aromatic compound with broad-spectrum antimicrobial activity that inhibits bacterial enoyl-acyl carrier protein reductase (ENR, FabI), a key enzyme in bacterial fatty acid synthesis required for cell membrane integrity and growth. It is widely used in consumer products (toothpastes, surgical scrubs, antimicrobial soaps) and has been investigated for treatment of infectious diseases and potential antiproliferative effects in cancer cell lines. Regulatory restrictions have been placed on triclosan in rinse-off consumer products due to concerns about endocrine disruption, …
Yes, Triclosan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL849. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5564. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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