Trimethobenzamide
Trimethobenzamide is an antiemetic agent that acts centrally by blocking dopamine receptors in the chemoreceptor trigger zone of the medulla, thereby suppressing nausea and vomiting. It is used to treat nausea and vomiting associated with various conditions including postoperative states and gastroenteritis, and is sometimes used as adjunctive therapy in Parkinson's disease patients experiencing drug-related nausea. Unlike phenothiazine antiemetics, it has a relatively low risk of extrapyramidal side effects.
Peso Molecular
388,5000 g/mol
LogP
2,30
TPSA
69,30 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
COc1cc(C(=O)NCc2ccc(OCCN(C)C)cc2)cc(OC)c1OC
InChI
InChI=1S/C21H28N2O5/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24)
Molecular Formula
C21H28N2O5
HBD / HBA
1 / 6
Ligações Rotacionáveis
10
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Trimethobenzamide is an antiemetic agent that acts centrally by blocking dopamine receptors in the chemoreceptor trigger zone of the medulla, thereby suppressing nausea and vomiting. It is used to treat nausea and vomiting associated with various conditions including postoperative states and gastroenteritis, and is sometimes used as adjunctive therapy in Parkinson's disease patients experiencing drug-related nausea. Unlike phenothiazine antiemetics, it has a relatively low risk of extrapyramidal side effects.
Yes, Trimethobenzamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201256. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5577. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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