Trospium

CHEMBL1888176 Phase 4 Aprovado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

392.5 g/mol

LogP

4.4

Phase

4

Trospium is a quaternary ammonium antimuscarinic agent that blocks muscarinic M3 receptors in the detrusor muscle of the bladder, reducing involuntary contractions and increasing bladder capacity. It is used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. Its quaternary structure limits CNS penetration, reducing cognitive side effects compared to tertiary antimuscarinics.

Peso Molecular

392,5000 g/mol

LogP

4,40

TPSA

46,50 Å²

Regra dos 5 de Lipinski

Aprovado

Áreas Terapêuticas

Chronic Obstructive Pulmonary Disease Alzheimer's Disease Schizophrenia Bipolar Disorder Obesity

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estrutura 2D

SVG PNG

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SMILES

O=C(O[C@H]1C[C@H]2CC[C@@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1

InChI

InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+

Molecular Formula

C25H30NO3+

HBD / HBA

1 / 3

Ligações Rotacionáveis

5

Átomos Pesados

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Perguntas frequentes

Trospium is a quaternary ammonium antimuscarinic agent that blocks muscarinic M3 receptors in the detrusor muscle of the bladder, reducing involuntary contractions and increasing bladder capacity. It is used to treat overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency. Its quaternary structure limits CNS penetration, reducing cognitive side effects compared to tertiary antimuscarinics.

Yes, Trospium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1888176. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5284632. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

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Estrutura

Dados Rápidos

Fórmula: C25H30NO3+
Sinônimos: 2

Links Externos

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Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.