Urofollitropin
Urofollitropin is a purified preparation of follicle-stimulating hormone (FSH) extracted and purified from the urine of postmenopausal women, used to stimulate follicular development and ovulation in the treatment of infertility. It is used in assisted reproductive technologies to stimulate multiple follicle development for egg retrieval and in ovulation induction for anovulatory infertility. Its urinary origin distinguishes it from recombinant FSH preparations (follitropin alfa and beta).
Peso Molecular
980,2000 g/mol
LogP
-1,50
TPSA
427,00 Ų
Regra dos 5 de Lipinski
Reprovado
Mecanismo de Ação
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
SMILES
CC[C@@H](C)C1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](CSSC[C@H](C(=O)N[C@@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@@H]3C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)[C@H](C)O
InChI
InChI=1S/C42H65N11O12S2/c1-6-21(4)33-40(63)52-34(22(5)54)41(64)49-28(16-31(44)56)37(60)50-29(19-67-66-18-25(43)35(58)47-27(38(61)51-33)15-23-9-11-24(55)12-10-23)42(65)53-13-7-8-30(53)39(62)48-26(14-20(2)3)36(59)46-17-32(45)57/h9-12,20-22,25-30,33-34,54-55H,6-8,13-19,43H2,1-5H3,(H2,44,56)(H2,45,57)(H,46,59)(H,47,58)(H,48,62)(H,49,64)(H,50,60)(H,51,61)(H,52,63)/t21-,22+,25-,26-,27-,28+,29-,30-,33?,34+/m1/s1
Molecular Formula
C42H65N11O12S2
HBD / HBA
12 / 15
Ligações Rotacionáveis
15
Átomos Pesados
67
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Urofollitropin is a purified preparation of follicle-stimulating hormone (FSH) extracted and purified from the urine of postmenopausal women, used to stimulate follicular development and ovulation in the treatment of infertility. It is used in assisted reproductive technologies to stimulate multiple follicle development for egg retrieval and in ovulation induction for anovulatory infertility. Its urinary origin distinguishes it from recombinant FSH preparations (follitropin alfa and beta).
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Yes, Urofollitropin is an approved drug. It has reached clinical phase 4. It is classified as a Unknown.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201520. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 73759969. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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