Vonoprazan
Vonoprazan is a potassium-competitive acid blocker (PCAB) that reversibly blocks the gastric H+/K+-ATPase proton pump by competitively competing with potassium ions, producing potent and prolonged suppression of gastric acid secretion without requiring activation by acid. It is used for treatment of erosive esophagitis, gastroesophageal reflux disease, and H. pylori eradication regimens, demonstrating faster onset and more consistent acid suppression than proton pump inhibitors (PPIs). Its potassium-competitive mechanism is active regardless of meal timing.
Peso Molecular
345,4000 g/mol
LogP
2,00
TPSA
72,40 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccnc2)c1
InChI
InChI=1S/C17H16FN3O2S/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14/h2-9,11-12,19H,10H2,1H3
Molecular Formula
C17H16FN3O2S
HBD / HBA
1 / 5
Ligações Rotacionáveis
5
Átomos Pesados
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Vonoprazan is a potassium-competitive acid blocker (PCAB) that reversibly blocks the gastric H+/K+-ATPase proton pump by competitively competing with potassium ions, producing potent and prolonged suppression of gastric acid secretion without requiring activation by acid. It is used for treatment of erosive esophagitis, gastroesophageal reflux disease, and H. pylori eradication regimens, demonstrating faster onset and more consistent acid suppression than proton pump inhibitors (PPIs). Its potassium-competitive mechanism is active regardless of meal timing.
Yes, Vonoprazan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2079130. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 15981397. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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