Moderate
Probable
Descrição
Carbamazepine reduces omeprazole plasma concentrations through CYP3A4 induction, potentially reducing the efficacy of acid suppression therapy.
Mecanismo
Carbamazepine induces CYP3A4 and CYP2C19, the primary enzymes metabolizing omeprazole, significantly increasing its clearance.
Significância Clínica
Omeprazole AUC may be reduced substantially; patients with acid reflux or peptic ulcer disease may experience symptom breakthrough.
Conduta
Monitor GI symptom control; omeprazole dose doubling may be needed; consider pantoprazole as an alternative with less CYP2C19 dependence.