Azithromycin vs Vancomycin

## Azithromycin vs Vancomycin: Overview

This comparison examines the pharmacological differences between **Azithromycin** and **Vancomycin**.

## Mechanism of Action

**Azithromycin**: Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis.

**Vancomycin**: Glycopeptide antibiotic inhibiting cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan precursors.

## Pharmacokinetics

**Half-life**: Azithromycin — 68 hours; Vancomycin — 4-6 hours.

## Chemical Properties

**Molecular Formula**: Azithromycin — C38H72N2O12; Vancomycin — C66H75Cl2N9O24.

**Molecular Weight**: Azithromycin — 748.9840 g/mol; Vancomycin — 1449.2500 g/mol.

**Type**: Azithromycin — Small molecule; Vancomycin — Small molecule.