Candesartan vs Captopril

## Candesartan vs Captopril: Overview

This comparison examines the pharmacological differences between **Candesartan** and **Captopril**.

## Mechanism of Action

**Candesartan**: Prodrug hydrolyzed to active form; selective angiotensin II type 1 receptor blocker.

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

## Pharmacokinetics

**Half-life**: Candesartan — 9 hours; Captopril — 1.9 hours.

## Chemical Properties

**Molecular Formula**: Candesartan — C33H34N6O6; Captopril — C9H15NO3S.

**Molecular Weight**: Candesartan — 610.6640 g/mol; Captopril — 217.2850 g/mol.

**Type**: Candesartan — Small molecule; Captopril — Small molecule.