Captopril vs Hydrochlorothiazide

## Captopril vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Captopril** and **Hydrochlorothiazide**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Captopril — 217.2850 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Captopril — Small molecule; Hydrochlorothiazide — Small molecule.