Captopril vs Losartan

## Captopril vs Losartan: Overview

This comparison examines the pharmacological differences between **Captopril** and **Losartan**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Losartan**: Angiotensin II receptor type 1 antagonist.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Losartan — 2 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Losartan — C22H23ClN6O.

**Molecular Weight**: Captopril — 217.2850 g/mol; Losartan — 422.9200 g/mol.

**Type**: Captopril — Small molecule; Losartan — Small molecule.