Captopril vs Ramipril

## Captopril vs Ramipril: Overview

This comparison examines the pharmacological differences between **Captopril** and **Ramipril**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Ramipril**: Prodrug converted to ramiprilat; ACE inhibitor.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Ramipril — 13-17 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Ramipril — C23H32N2O5.

**Molecular Weight**: Captopril — 217.2850 g/mol; Ramipril — 416.5120 g/mol.

**Type**: Captopril — Small molecule; Ramipril — Small molecule.