Celecoxib vs Tofacitinib

## Celecoxib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Celecoxib** and **Tofacitinib**.

## Mechanism of Action

**Celecoxib**: Selective COX-2 inhibitor.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Celecoxib — 11 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Celecoxib — C17H14F3N3O2S; Tofacitinib — C16H20N6O.

**Molecular Weight**: Celecoxib — 381.3730 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Celecoxib — Small molecule; Tofacitinib — Small molecule.