Bosutinib
A tyrosine kinase inhibitor that targets BCR-ABL and certain SRC kinases, used to treat chronic myelogenous leukemia in patients who have failed or are intolerant of prior therapies. By blocking the abnormal BCR-ABL protein, it slows the growth of leukemia cells. Gastrointestinal side effects are common, particularly early in treatment.
Молекулярная масса
530,4000 g/mol
LogP
5,40
TPSA
82,90 Ų
Правило пяти Липинского
Не соответствует
Терапевтические области
Механизм действия
Selectively inhibits specific receptor tyrosine kinases involved in tumor cell proliferation, angiogenesis, and survival signaling. By blocking ATP binding to the kinase domain, it prevents phosphorylation cascades that drive cancer cell growth.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively inhibits specific receptor tyrosine kinases involved in tumor cell proliferation, angiogenesis, and survival signaling. By blocking ATP binding to the kinase domain, it prevents phosphorylation cascades that drive cancer …
2D Структура
Cite this structure
Embed this structure
SMILES
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl
InChI
InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
Molecular Formula
C26H29Cl2N5O3
HBD / HBA
1 / 8
Вращаемые Связи
9
Тяжёлые Атомы
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Часто задаваемые вопросы
A tyrosine kinase inhibitor that targets BCR-ABL and certain SRC kinases, used to treat chronic myelogenous leukemia in patients who have failed or are intolerant of prior therapies. By blocking the abnormal BCR-ABL protein, it slows the growth of leukemia cells. Gastrointestinal side effects are common, particularly early in treatment.
Selectively inhibits specific receptor tyrosine kinases involved in tumor cell proliferation, angiogenesis, and survival signaling. By blocking ATP binding to the kinase domain, it prevents phosphorylation cascades that drive cancer cell growth.
Yes, Bosutinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL288441. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5328940. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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