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Fostamatinib

CHEMBL2103830 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
580.5 g/mol
LogP
1.6
Phase
4

This oral medication inhibits a signaling enzyme called SYK that is involved in the destruction of platelets by the immune system, helping to raise platelet counts in certain immune conditions. It is used to treat immune thrombocytopenia and has been studied in rheumatoid arthritis.

Молекулярная масса

580,5000 g/mol

LogP

1,60

TPSA

187,00 Ų

Правило пяти Липинского

Не соответствует

Терапевтические области

Ovarian Cancer Rheumatoid Arthritis Systemic Lupus Erythematosus Lymphoma Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H26FN6O9P

                    

                    
                    

                        
HBD / HBA

                        
4 / 15

                    

                    
                    

                        
Вращаемые Связи

                        
10

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
40

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
This oral medication inhibits a signaling enzyme called SYK that is involved in the destruction of platelets by the immune system, helping to raise platelet counts in certain immune conditions. It is used to treat immune thrombocytopenia and has been studied in rheumatoid arthritis.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Fostamatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2103830.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11671467.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.