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Silodosin

CHEMBL24778 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
495.5 g/mol
LogP
3.6
Phase
4

Silodosin is a highly selective alpha-1A adrenergic receptor antagonist used for the symptomatic treatment of benign prostatic hyperplasia (BPH) and has been investigated for prostate cancer-related urinary symptoms. Its selectivity for the alpha-1A subtype predominant in the prostate and bladder neck smooth muscle provides effective urinary flow improvement with minimal cardiovascular effects such as orthostatic hypotension. It is administered orally and achieves rapid symptomatic relief of lower urinary tract symptoms.

Молекулярная масса

495,5000 g/mol

LogP

3,60

TPSA

97,10 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Benign Prostatic Hyperplasia Prostate Cancer

Механизм действия

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F

                

                

                
                

                    
InChI

                    
InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H32F3N3O4

                    

                    
                    

                        
HBD / HBA

                        
3 / 9

                    

                    
                    

                        
Вращаемые Связи

                        
13

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Silodosin is a highly selective alpha-1A adrenergic receptor antagonist used for the symptomatic treatment of benign prostatic hyperplasia (BPH) and has been investigated for prostate cancer-related urinary symptoms. Its selectivity for the alpha-1A subtype predominant in the prostate and bladder neck smooth muscle provides effective urinary flow improvement with minimal cardiovascular effects such as orthostatic hypotension. It is administered orally and achieves rapid symptomatic relief of lower urinary tract symptoms.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Silodosin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL24778.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5312125.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.