Silodosin
Silodosin is a highly selective alpha-1A adrenergic receptor antagonist used for the symptomatic treatment of benign prostatic hyperplasia (BPH) and has been investigated for prostate cancer-related urinary symptoms. Its selectivity for the alpha-1A subtype predominant in the prostate and bladder neck smooth muscle provides effective urinary flow improvement with minimal cardiovascular effects such as orthostatic hypotension. It is administered orally and achieves rapid symptomatic relief of lower urinary tract symptoms.
Molecular Weight
495.5000 g/mol
LogP
3.60
TPSA
97.10 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D Structure
Cite this structure
Embed this structure
SMILES
C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F
InChI
InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
Molecular Formula
C25H32F3N3O4
HBD / HBA
3 / 9
Rotatable Bonds
13
Heavy Atoms
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
Silodosin is a highly selective alpha-1A adrenergic receptor antagonist used for the symptomatic treatment of benign prostatic hyperplasia (BPH) and has been investigated for prostate cancer-related urinary symptoms. Its selectivity for the alpha-1A subtype predominant in the prostate and bladder neck smooth muscle provides effective urinary flow improvement with minimal cardiovascular effects such as orthostatic hypotension. It is administered orally and achieves rapid symptomatic relief of lower urinary tract symptoms.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Silodosin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL24778. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5312125. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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