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Trichlormethiazide

CHEMBL1054 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
380.7 g/mol
LogP
0.6
Phase
4

Trichlormethiazide is a thiazide diuretic that inhibits the sodium-chloride symporter (NCC) in the distal convoluted tubule, reducing sodium and chloride reabsorption and increasing urinary excretion of sodium, chloride, potassium, and water. It is used for the treatment of hypertension and edematous conditions including congestive heart failure and renal disease, lowering blood pressure through initial volume reduction and later through peripheral vasodilation. Like other thiazides, it can cause hypokalemia, hyponatremia, and hyperuricemia as metabolic adverse effects.

Молекулярная масса

380,7000 g/mol

LogP

0,60

TPSA

135,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
NS(=O)(=O)c1cc2c(cc1Cl)NC(C(Cl)Cl)NS2(=O)=O

                

                

                
                

                    
InChI

                    
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H8Cl3N3O4S2

                    

                    
                    

                        
HBD / HBA

                        
3 / 7

                    

                    
                    

                        
Вращаемые Связи

                        
2

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Trichlormethiazide is a thiazide diuretic that inhibits the sodium-chloride symporter (NCC) in the distal convoluted tubule, reducing sodium and chloride reabsorption and increasing urinary excretion of sodium, chloride, potassium, and water. It is used for the treatment of hypertension and edematous conditions including congestive heart failure and renal disease, lowering blood pressure through initial volume reduction and later through peripheral vasodilation. Like other thiazides, it can cause hypokalemia, hyponatremia, and hyperuricemia as metabolic adverse effects.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Trichlormethiazide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1054.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5560.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.