Trichlormethiazide
Trichlormethiazide is a thiazide diuretic that inhibits the sodium-chloride symporter (NCC) in the distal convoluted tubule, reducing sodium and chloride reabsorption and increasing urinary excretion of sodium, chloride, potassium, and water. It is used for the treatment of hypertension and edematous conditions including congestive heart failure and renal disease, lowering blood pressure through initial volume reduction and later through peripheral vasodilation. Like other thiazides, it can cause hypokalemia, hyponatremia, and hyperuricemia as metabolic adverse effects.
Peso Molecular
380,7000 g/mol
LogP
0,60
TPSA
135,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estrutura 2D
Cite this structure
Embed this structure
SMILES
NS(=O)(=O)c1cc2c(cc1Cl)NC(C(Cl)Cl)NS2(=O)=O
InChI
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
Molecular Formula
C8H8Cl3N3O4S2
HBD / HBA
3 / 7
Ligações Rotacionáveis
2
Átomos Pesados
20
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
Trichlormethiazide is a thiazide diuretic that inhibits the sodium-chloride symporter (NCC) in the distal convoluted tubule, reducing sodium and chloride reabsorption and increasing urinary excretion of sodium, chloride, potassium, and water. It is used for the treatment of hypertension and edematous conditions including congestive heart failure and renal disease, lowering blood pressure through initial volume reduction and later through peripheral vasodilation. Like other thiazides, it can cause hypokalemia, hyponatremia, and hyperuricemia as metabolic adverse effects.
Yes, Trichlormethiazide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1054. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5560. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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