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Valbenazine

CHEMBL2364639 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
418.6 g/mol
LogP
4.3
Phase
4

Valbenazine is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor that depletes monoamines (particularly dopamine) from presynaptic nerve terminals by blocking their re-uptake into synaptic vesicles, reducing dopaminergic activity in striatal pathways. It is approved for the treatment of tardive dyskinesia (TD), an involuntary movement disorder caused by prolonged dopamine receptor antagonist therapy. Its VMAT2 selectivity reduces off-target effects compared to older VMAT inhibitors like tetrabenazine.

Молекулярная масса

418,6000 g/mol

LogP

4,30

TPSA

74,00 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Schizophrenia Bipolar Disorder Major Depressive Disorder

Механизм действия

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Механизм

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1cc2c(cc1OC)[C@H]1C[C@@H](OC(=O)[C@@H](N)C(C)C)[C@H](CC(C)C)CN1CC2

                

                

                
                

                    
InChI

                    
InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H38N2O4

                    

                    
                    

                        
HBD / HBA

                        
1 / 6

                    

                    
                    

                        
Вращаемые Связи

                        
8

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Valbenazine is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor that depletes monoamines (particularly dopamine) from presynaptic nerve terminals by blocking their re-uptake into synaptic vesicles, reducing dopaminergic activity in striatal pathways. It is approved for the treatment of tardive dyskinesia (TD), an involuntary movement disorder caused by prolonged dopamine receptor antagonist therapy. Its VMAT2 selectivity reduces off-target effects compared to older VMAT inhibitors like tetrabenazine.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Valbenazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2364639.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 24795069.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.