Valbenazine
Valbenazine is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor that depletes monoamines (particularly dopamine) from presynaptic nerve terminals by blocking their re-uptake into synaptic vesicles, reducing dopaminergic activity in striatal pathways. It is approved for the treatment of tardive dyskinesia (TD), an involuntary movement disorder caused by prolonged dopamine receptor antagonist therapy. Its VMAT2 selectivity reduces off-target effects compared to older VMAT inhibitors like tetrabenazine.
Moleküler Ağırlık
418,6000 g/mol
LogP
4,30
TPSA
74,00 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
2D Yapı
Cite this structure
Embed this structure
SMILES
COc1cc2c(cc1OC)[C@H]1C[C@@H](OC(=O)[C@@H](N)C(C)C)[C@H](CC(C)C)CN1CC2
InChI
InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1
Molecular Formula
C24H38N2O4
HBD / HBA
1 / 6
Döndürülebilir Bağlar
8
Ağır Atomlar
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Valbenazine is a highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor that depletes monoamines (particularly dopamine) from presynaptic nerve terminals by blocking their re-uptake into synaptic vesicles, reducing dopaminergic activity in striatal pathways. It is approved for the treatment of tardive dyskinesia (TD), an involuntary movement disorder caused by prolonged dopamine receptor antagonist therapy. Its VMAT2 selectivity reduces off-target effects compared to older VMAT inhibitors like tetrabenazine.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Valbenazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2364639. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 24795069. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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