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Veralipride

CHEMBL2105581 Phase 4 Одобрено Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
383.5 g/mol
LogP
0.8
Phase
4

Veralipride is a substituted benzamide antidopaminergic agent that blocks dopamine D2 receptors, developed for the management of menopausal hot flashes as an alternative to hormone replacement therapy. It was withdrawn in several countries due to adverse neurological effects including tardive dyskinesia and other extrapyramidal symptoms associated with its dopamine antagonist mechanism. Its use demonstrated the role of dopaminergic pathways in thermoregulation.

Молекулярная масса

383,5000 g/mol

LogP

0,80

TPSA

119,00 Ų

Правило пяти Липинского

Соответствует

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C17H25N3O5S/c1-4-7-20-8-5-6-12(20)11-19-17(21)14-9-13(26(18,22)23)10-15(24-2)16(14)25-3/h4,9-10,12H,1,5-8,11H2,2-3H3,(H,19,21)(H2,18,22,23)

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H25N3O5S

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
Вращаемые Связи

                        
8

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
Veralipride is a substituted benzamide antidopaminergic agent that blocks dopamine D2 receptors, developed for the management of menopausal hot flashes as an alternative to hormone replacement therapy. It was withdrawn in several countries due to adverse neurological effects including tardive dyskinesia and other extrapyramidal symptoms associated with its dopamine antagonist mechanism. Its use demonstrated the role of dopaminergic pathways in thermoregulation.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Veralipride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2105581.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 47979.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.