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Veralipride

CHEMBL2105581 Phase 4 Approved Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
383.5 g/mol
LogP
0.8
Phase
4

Veralipride is a substituted benzamide antidopaminergic agent that blocks dopamine D2 receptors, developed for the management of menopausal hot flashes as an alternative to hormone replacement therapy. It was withdrawn in several countries due to adverse neurological effects including tardive dyskinesia and other extrapyramidal symptoms associated with its dopamine antagonist mechanism. Its use demonstrated the role of dopaminergic pathways in thermoregulation.

Molecular Weight

383.5000 g/mol

LogP

0.80

TPSA

119.00 Ų

Lipinski RO5

Pass

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Structure

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C17H25N3O5S/c1-4-7-20-8-5-6-12(20)11-19-17(21)14-9-13(26(18,22)23)10-15(24-2)16(14)25-3/h4,9-10,12H,1,5-8,11H2,2-3H3,(H,19,21)(H2,18,22,23)

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H25N3O5S

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
Rotatable Bonds

                        
8

                    

                    
                    
                    

                        
Heavy Atoms

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Frequently Asked Questions

                

                    
                    

                        
                        

                            
Veralipride is a substituted benzamide antidopaminergic agent that blocks dopamine D2 receptors, developed for the management of menopausal hot flashes as an alternative to hormone replacement therapy. It was withdrawn in several countries due to adverse neurological effects including tardive dyskinesia and other extrapyramidal symptoms associated with its dopamine antagonist mechanism. Its use demonstrated the role of dopaminergic pathways in thermoregulation.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Veralipride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2105581.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 47979.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Medical Disclaimer

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.