Veralipride

CHEMBL2105581 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

383.5 g/mol

LogP

0.8

Phase

4

Veralipride is a substituted benzamide antidopaminergic agent that blocks dopamine D2 receptors, developed for the management of menopausal hot flashes as an alternative to hormone replacement therapy. It was withdrawn in several countries due to adverse neurological effects including tardive dyskinesia and other extrapyramidal symptoms associated with its dopamine antagonist mechanism. Its use demonstrated the role of dopaminergic pathways in thermoregulation.

Moleküler Ağırlık

383,5000 g/mol

LogP

0,80

TPSA

119,00 Å²

Lipinski RO5

Geçer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

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SMILES

C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC

InChI

InChI=1S/C17H25N3O5S/c1-4-7-20-8-5-6-12(20)11-19-17(21)14-9-13(26(18,22)23)10-15(24-2)16(14)25-3/h4,9-10,12H,1,5-8,11H2,2-3H3,(H,19,21)(H2,18,22,23)

Molecular Formula

C17H25N3O5S

HBD / HBA

2 / 7

Döndürülebilir Bağlar

8

Ağır Atomlar

26

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

Veralipride is a substituted benzamide antidopaminergic agent that blocks dopamine D2 receptors, developed for the management of menopausal hot flashes as an alternative to hormone replacement therapy. It was withdrawn in several countries due to adverse neurological effects including tardive dyskinesia and other extrapyramidal symptoms associated with its dopamine antagonist mechanism. Its use demonstrated the role of dopaminergic pathways in thermoregulation.

Yes, Veralipride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105581. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 47979. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Formül: C17H25N3O5S

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.