mTOR Inhibitor
A drug that inhibits the mechanistic target of rapamycin (mTOR), a serine/threonine kinase that integrates growth factor and nutrient signaling to regulate cell growth, proliferation, and survival. mTOR inhibitors suppress T and B lymphocyte activation and have antiproliferative effects on tumor cells and vascular smooth muscle. They are used in transplant immunosuppression and oncology.
Примеры
- Sirolimus (rapamycin) — transplant rejection prophylaxis, drug-eluting stents
- Everolimus — renal cell carcinoma, breast cancer, tuberous sclerosis
- Temsirolimus — IV mTOR inhibitor for advanced renal cell carcinoma
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A drug that inhibits the mechanistic target of rapamycin (mTOR), a serine/threonine kinase that integrates growth factor and nutrient signaling to regulate cell growth, proliferation, and survival. mTOR inhibitors suppress …