Receptor Desensitization
Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.
Примеры
- Beta-2 agonist tachyphylaxis
- Opioid tolerance
- Nicotinic receptor desensitization
Знаете ли вы?
Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.