Описание
Bupropion inhibits CYP2D6, significantly increasing venlafaxine plasma concentrations, which may enhance both therapeutic and adverse serotonergic effects.
Механизм
Bupropion is a moderate-to-potent CYP2D6 inhibitor; venlafaxine is extensively metabolized by CYP2D6 to its active O-desmethylvenlafaxine metabolite, resulting in increased venlafaxine exposure.
Клиническое значение
Clinical studies show increased venlafaxine AUC and Cmax with concurrent bupropion; additive noradrenergic effects may raise blood pressure.
Тактика ведения
Monitor blood pressure and serotonin syndrome symptoms; consider venlafaxine dose reduction when adding bupropion.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.