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Venlafaxine

CHEMBL637 Phase 4 Одобрено Small molecule
Half-Life
5 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
277.4 g/mol
LogP
2.9
Phase
4

A serotonin-norepinephrine reuptake inhibitor, venlafaxine raises brain levels of both neurotransmitters to help regulate mood and anxiety. It treats major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. Marketed as Effexor, it has the formula C17H27NO2. Because it can raise blood pressure, particularly at higher doses, treatment is accompanied by blood-pressure monitoring, and abrupt discontinuation can produce withdrawal symptoms.

This serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps regulate mood and anxiety. Blood pressure should be monitored as it can cause small increases, particularly at higher doses.

Молекулярная масса

277,4020 g/mol

LogP

2,90

TPSA

32,70 Ų

Правило пяти Липинского

Соответствует

Терапевтические области

Psychiatry Generalized Anxiety Disorder Major Depressive Disorder

Классы препаратов

N — N - Nervous System

Механизм действия

Serotonin-norepinephrine reuptake inhibitor (SNRI).

Pharmacokinetics (PK)

Half-Life 5 hours

Pharmacodynamics (PD)

Механизм

Serotonin-norepinephrine reuptake inhibitor (SNRI).

2D Структура

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H27NO2

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Вращаемые Связи

                        
5

                    

                    
                    
                    

                        
Тяжёлые Атомы

                        
20

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            SLC6A4 (Serotonin Transporter)
                            Inhibitor
                        

                        
                        Primary Target
                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Venlafaxine + Tramadol
                            
                        

                        
                        
Venlafaxine and tramadol together pose a high risk of serotonin syndrome due to complementary serotonergic mechanisms.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Venlafaxine + Bupropion
                            
                        

                        
                        
Bupropion inhibits CYP2D6, significantly increasing venlafaxine plasma concentrations, which may enhance both therapeutic and adverse serotonergic effects.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Venlafaxine + Carbamazepine
                            
                        

                        
                        
Carbamazepine significantly reduces venlafaxine plasma concentrations through CYP3A4 induction, potentially reducing antidepressant efficacy.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Часто задаваемые вопросы

                

                    
                    

                        
                        

                            
This serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps regulate mood and anxiety. Blood pressure should be monitored as it can cause small increases, particularly at higher doses.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Serotonin-norepinephrine reuptake inhibitor (SNRI).

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Venlafaxine: Half-life: 5 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Venlafaxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Acetaminophen
                            Small molecule
                        
                        
                        
                            Aspirin
                            Small molecule
                        
                        
                        
                            Sertraline
                            Small molecule
                        
                        
                        
                            Escitalopram
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL637.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5656.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Медицинский отказ от ответственности

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.