SLC6A4 (Serotonin Transporter)
SLC6A4
Sodium-dependent serotonin transporter responsible for reuptake of 5-HT from the synaptic cleft.
Функция
Primary target for SSRIs and SNRIs. Inhibition increases synaptic serotonin.
Препараты, действующие на данную мишень
| Препарат | Действие | Первичный |
|---|---|---|
| Sertraline | Inhibitor | Да |
| Escitalopram | Inhibitor | Да |
| Fluoxetine | Inhibitor | Да |
| Duloxetine | Inhibitor | Да |
| Venlafaxine | Inhibitor | Да |
| Tramadol | Inhibitor | Да |
| Ondansetron | Other | Да |
| Quetiapine | Inhibitor | — |
| Bupropion | Inhibitor | — |
| Trazodone | Inhibitor | — |
| Sumatriptan | Other | — |
| Aripiprazole | Partial Agonist | — |