SLC6A4 (Serotonin Transporter)
SLC6A4
Sodium-dependent serotonin transporter responsible for reuptake of 5-HT from the synaptic cleft.
Function
Primary target for SSRIs and SNRIs. Inhibition increases synaptic serotonin.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Duloxetine | Inhibitor | Yes |
| Escitalopram | Inhibitor | Yes |
| Fluoxetine | Inhibitor | Yes |
| Sertraline | Inhibitor | Yes |
| Venlafaxine | Inhibitor | Yes |
| Trazodone | Inhibitor | — |
| Tramadol | Inhibitor | — |