ABCB1 (P-glycoprotein)
ABCB1
ATP-dependent efflux transporter limiting oral bioavailability and CNS penetration.
Function
Pumps substrates out of cells at the blood-brain barrier and intestinal epithelium.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Trimethoprim | Inhibitor | Yes |
| Azithromycin | Inhibitor | Yes |
| Donepezil | Substrate | Yes |
| Digoxin | Substrate | Yes |
| Methotrexate | Substrate | Yes |
| Clindamycin | Substrate | Yes |
| Acyclovir | Substrate | Yes |
| Oseltamivir | Substrate | Yes |
| Colchicine | Substrate | Yes |
| Amoxicillin | Substrate | Yes |
| Cephalexin | Substrate | Yes |
| Carbamazepine | Inducer | — |
| Omeprazole | Inhibitor | — |
| Cyclosporine | Inhibitor | — |
| Lithium Carbonate | Other | — |
| Gabapentin | Other | — |
| Tacrolimus | Substrate | — |
| Metformin | Substrate | — |
| Atorvastatin | Substrate | — |
| Levothyroxine | Substrate | — |
| Rosuvastatin | Substrate | — |
| Morphine | Substrate | — |
| Empagliflozin | Substrate | — |
| Rivaroxaban | Substrate | — |
| Dabigatran | Substrate | — |
| Ramipril | Substrate | — |
| Valsartan | Substrate | — |
| Naproxen | Substrate | — |
| Levodopa | Substrate | — |
| Phenytoin | Substrate | — |
| Aspirin | Substrate | — |