Описание
Fluconazole inhibits the metabolism of ondansetron and both drugs prolong the QT interval, creating a compounded arrhythmia risk.
Механизм
Fluconazole inhibits CYP3A4 and CYP2C9, reducing ondansetron clearance and increasing its plasma concentrations; both drugs independently block hERG channels.
Клиническое значение
The combination can markedly increase ondansetron exposure and QTc prolongation; cases of torsades de pointes have been documented.
Тактика ведения
Avoid combination or use the lowest effective ondansetron dose with ECG monitoring; correct hypokalemia before initiating.
Медицинский отказ от ответственности
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.