Fluconazole vs Tacrolimus

## Fluconazole vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Fluconazole** and **Tacrolimus**.

## Mechanism of Action

**Fluconazole**: Inhibits fungal CYP51 (lanosterol 14-alpha-demethylase).

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Fluconazole — 30 hours; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Fluconazole — C13H12F2N6O; Tacrolimus — C44H69NO12.

**Molecular Weight**: Fluconazole — 306.2710 g/mol; Tacrolimus — 804.0180 g/mol.

**Type**: Fluconazole — Small molecule; Tacrolimus — Small molecule.