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Capsaicin

CHEMBL294199 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
305.4 g/mol
LogP
3.6
Phase
4

The active compound in chili peppers used topically and in patch form to relieve pain associated with conditions including neuropathy, arthritis, and post-herpetic neuralgia. It works by initially stimulating and then desensitizing pain-sensing nerve fibers through depletion of substance P and transient TRPV1 receptor overstimulation. Initial burning or stinging at the application site is common.

น้ำหนักโมเลกุล

305.4000 g/mol

LogP

3.60

TPSA

58.60 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Dermatology Pain Management Rheumatoid Arthritis Asthma Chronic Obstructive Pulmonary Disease Parkinson's Disease Migraine Gastroesophageal Reflux Disease Psoriasis Stroke Obesity Hypertension Breast Cancer Gout Chronic Pain Prostate Cancer

กลไกการออกฤทธิ์

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O

                

                

                
                

                    
InChI

                    
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H27NO3

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
พันธะที่หมุนได้

                        
9

                    

                    
                    
                    

                        
อะตอมหนัก

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
The active compound in chili peppers used topically and in patch form to relieve pain associated with conditions including neuropathy, arthritis, and post-herpetic neuralgia. It works by initially stimulating and then desensitizing pain-sensing nerve fibers through depletion of substance P and transient TRPV1 receptor overstimulation. Initial burning or stinging at the application site is common.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Capsaicin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL294199.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1548943.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.