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Cefpodoxime Proxetil

CHEMBL1201016 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
557.6 g/mol
LogP
0.6
Phase
4

Prodrug esterification allows cefpodoxime proxetil to be absorbed from the gut, after which de-esterification in the intestinal wall liberates the active third-generation cephalosporin cefpodoxime. The active compound binds penicillin-binding proteins and blocks the terminal transpeptidation reaction of peptidoglycan assembly; the resulting defects leave the cell wall osmotically unstable and bacteriolysis follows. Its broad spectrum covers common respiratory pathogens, and clinical use spans ear, throat and sinus infections as well as urinary tract infection. Unlike several oral beta-lactams, absorption is enhanced rather than impaired by food. The prodrug is a small molecule of formula C21H27N5O9S2 with a mass near 557.6 g/mol, approved and developed through the final clinical phase.

An oral third-generation cephalosporin prodrug that is de-esterified in the intestinal wall to the active compound cefpodoxime. It provides broad-spectrum activity against common respiratory pathogens and is used for ear, throat, sinus, and urinary tract infections. Food enhances its absorption, and it should be taken with meals for optimal effect.

น้ำหนักโมเลกุล

557.6000 g/mol

LogP

0.60

TPSA

235.00 Ų

Lipinski RO5

ไม่ผ่าน

ด้านการรักษา

Urology

กลไกการออกฤทธิ์

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COCC1=C(C(=O)OC(C)OC(=O)OC(C)C)N2C(=O)[C@@H](NC(=O)/C(=N\OC)c3csc(N)n3)[C@H]2SC1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H27N5O9S2

                    

                    
                    

                        
HBD / HBA

                        
2 / 14

                    

                    
                    

                        
พันธะที่หมุนได้

                        
13

                    

                    
                    
                    

                        
อะตอมหนัก

                        
37

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
An oral third-generation cephalosporin prodrug that is de-esterified in the intestinal wall to the active compound cefpodoxime. It provides broad-spectrum activity against common respiratory pathogens and is used for ear, throat, sinus, and urinary tract infections. Food enhances its absorption, and it should be taken with meals for optimal effect.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cefpodoxime Proxetil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201016.
                Open-access bioactivity database.
            
        
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                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6526396.
                Chemical information database.
            
        
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Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.